REAKTİF TROMBOSİTOZ NEDENLERİ
Major causes of reactive thrombocytosis
Nonmalignant hematologic conditions |
- Acute blood loss
- Acute hemolytic anemia
- Iron deficiency anemia
- Treatment of vitamin B12 deficiency
- Rebound effect after treatment of ITP
- Rebound effect after ethanol-induced thrombocytopenia
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Malignant conditions |
- Metastatic cancer
- Lymphoma
- Rebound effect following use of myelosuppressive agents
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Acute and chronic inflammatory conditions |
- Rheumatologic disorders, vasculitides
- Inflammatory bowel disease
- Celiac disease
- Functional and surgical asplenia
- POEMS syndrome (osteosclerotic myeloma)
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Tissue damage |
- Thermal burns
- Myocardial infarction
- Severe trauma
- Acute pancreatitis
- Post-surgical period, especially post-splenectomy
- Coronary artery bypass procedures
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Infections |
- Chronic infections
- Tuberculosis
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Exercise |
Allergic reactions |
Chronic renal disease |
- Renal failure
- Nephrotic syndrome
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Reaction to medications |
- Vincristine
- Epinephrine, glucocorticoids
- Interleukin-1B
- All-trans retinoic acid
- Thrombopoietin, thrombopoietin mimetics
- Low molecular weight heparins (enoxaparin)
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Proposed revised WHO criteria for essential thrombocythemia (ET)
Proposed criteria for ET |
- Sustained platelet count ≥450 x 109/L*
- Bone marrow biopsy specimen showing proliferation mainly of the megakaryocytic lineage with increased numbers of enlarged, mature megakaryocytes; no significant increase or left-shift of neutrophil granulopoiesis or erythropoiesis
- Not meeting WHO criteria for PV•, PMFΔ, CML◊, MDS§ or other myeloid neoplasm
- Demonstration of JAK2 617V>F or other clonal marker, or in the absence of a clonal marker, no evidence for reactive thrombocytosis¥
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Diagnosis requires meeting all four criteria.
